CMEC (carboxymethyl ethoxy ethyl cellulose) has cellulose as a raw material and is mixed ether than can obtain partial carboxymethylation or ethylation.
CMEC (Carboxy methyl ethyl cellulose) is made of cellulose and is mixed ether by partial carboxymethylation or ethylation. Listed in JPE (Japan Pharmaceutical Excipients) and this is mainly used as a base for enteric film coating and controlled-release formulation. In addition, it is used as a carrier for solid dispersion with the aim of improving the solubility of poorly soluble drugs.
CMEC (carboxymethyl ethoxy ethyl cellulose) has cellulose as a raw material and is mixed ether than can obtain partial carboxymethylation or ethylation.
CMEC (Carboxy methyl ethyl cellulose) is made of cellulose and is mixed ether by partial carboxymethylation or ethylation. Listed in JPE (Japan Pharmaceutical Excipients) and this is mainly used as a base for enteric film coating and controlled-release formulation. In addition, it is used as a carrier for solid dispersion with the aim of improving the solubility of poorly soluble drugs.
Structural Formula
Molecular Weight
| Weighted mean molecular (Mw) | Number average molecular weight (Mn) | Variance ratio (Mw/Mn) |
| 4.9×10-4 | 1.4×10-4 | 3.5 |
Solubility
Insoluble in water but has good solubility in water/ethanol solution (70 – 90% ethanol).
| Formulation | Dissolution method（recommended） | |
| CMEC | 8.0% | Add CMEC to water : ethanol = 1 : 0.5 and dispersed. While stirring, the remaining ethanol is added and dissolved. The solution without lumps can be obtained. |
| Ethanol | 73.6% | |
| Water | 18.4% | |
Features
- High stability Chemically stableConsisting of ether linkage, it is chemically stable and hydrolysis is difficult.
- Disintegration of pH dependency depends on pHThe disintegration behaviour of tablet coated with CMEC depends on pH, independent of buffer solution type. Low pH gives slow disintegration and high pH gives fast disintegration.
It is possible to use this as an enteric base through controlled-release drugs using these properties.
In addition, the combination with controlled release base of pH independency enables to form various dissolution patterns. - As a Matrix-Forming MaterialCMEC is also used for a matrix-forming material with API.
By changing the ratio of API and CMEC, it is possible to control releasing speed. - Liquation Improvement for Insoluble Improve dissolution of Poorly Soluble DrugsCMEC is a carrier of solid dispersion for improving solubility of poorly soluble API.
- Protective coating for sugar-coated tabletCMEC film thickness apprx. 100μm has enough moisture prevention.
It is effective to use CMEC as protect coating agent on sugar-coated tablets containing water-sensitive API.